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M9490475.TXT
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1994-09-19
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Document 0475
DOCN M9490475
TI [Clinical and prognostic significance of cellular immunity factors in
patients with chronic liver diseases]
DT 9411
AU Podymova SD; Rachvelishvili NB
SO Vestn Ross Akad Med Nauk. 1994;(5):14-8. Unique Identifier : AIDSLINE
MED/94332010
AB The paper presents the results of comprehensive studies of quantitative
and functional parameters of cellular immunity in 283 patients with
chronic liver diseases, using various rosette tests and monoclonal
antibody phenotyping of immunocompetent cells. The pattern of changes in
blood immunocompetent cells and immunoglobulins allows prediction of the
natural history of chronic active hepatitis and hepatic cirrhosis of
viral and alcoholic origin. The data on autorosette-forming and
hepatic-specific lipoprotein-sensitive rosette-forming cells were found
to be the most informative. As compared to health, there were
substantial changes in the subpopulation composition of immunocompetent
cells and immunoglobulins in hepatic cirrhosis. The changes in
immunoregulatory theophylline-resistant (OKT4+, OKT8+, T mu and T gamma)
and theophylline-sensitive E-rosetting, as well as effector (ICO11+ and
ICOHM1+) cells were the leading immunopathogenetic link of hepatic
cirrhosis. In the latter, the subpopulation composition of
immunocompetent cells depended on the activity of a pathological
process, the state of compensation, as well as the levels of HBsAg and
blood anti-delta-antibodies. The subpopulation analysis of
immunocompetent cells enabled the author to outline the specific
features of the immune status of etiological types, as well as
predictive types of chronic active hepatitis and hepatic cirrhosis,
which may serve as evidence for goal-oriented immunomodulating therapy.
DE Adolescence Adult Aged Antibodies, Monoclonal Biological
Markers/BLOOD CD4-CD8 Ratio English Abstract Female Hepatitis
B/*IMMUNOLOGY Hepatitis B Surface Antigens/*BLOOD Hepatitis, Chronic
Active/*IMMUNOLOGY Human Immunocompetence Immunoglobulins/*BLOOD
Liver Cirrhosis, Alcoholic/*IMMUNOLOGY Male Middle Age Phenotype
Prognosis Rosette Formation T-Lymphocytes/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).